Background:

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level.

Applications:

ELISA, IHC

Name of antibody:

WNT6

Immunogen:

Synthetic peptide of humanWNT6

Full name:

wingless-type MMTV integration site family, member 6

SwissProt:

Q9Y6F9

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and Human esophagus cancer

IHC Recommend dilution:

25-100